抗菌肽联合传统抗菌药物对抗细菌耐药性研究进展

Advances in the combination of antimicrobial peptides with traditional antimicrobial agents against bacterial antimicrobial resistance

摘要:

抗菌药物滥用导致细菌耐药形势不断加剧, 细菌耐药性已成为日益严重的公共卫生问题。本文介绍不同抗菌药物如何发挥抗菌作用, 以及细菌通过改变细胞膜通透性等方式产生耐药性的机制。为解决细菌耐药性问题, 学者们提出了抗菌药物联合应用的协同抗菌策略, 以期通过多靶点、多途径的作用方式, 降低细菌产生耐药的概率, 同时提高抗菌效力。本文从协同抗菌机制出发, 对不同抗菌药物联合应用的协同抗菌作用进行综述, 并重点介绍抗菌肽与传统抗菌药物联合应用的协同效果, 以及在不同领域应用的研究进展, 旨在进一步推动抗菌肽等新型抗菌药物应用策略创新, 抑制细菌耐药性的发展。

Abstract:

The abuse of antimicrobial agents has led to a growing problem of bacterial antimicrobial resistance, and bacterial antimicrobial resistance has become a increasingly serious public health issue. This review introduces how different antimicrobial agents exert their antimicrobial effects and the mechanisms of producing bacterial antimicrobial resistance through changing cell membrane permeability, etc. In order to solve the problem of bacterial antimicrobial resistance, researchers have proposed a synergetic antimicrobial strategy by combining different antimicrobial agents, aiming to reduce the probability of bacterial resistance and improve antimicrobial efficacy through multi-target and multi-pathway action. This paper reviews the synergetic antimicrobial effects of the combined application of different antimicrobial agents from the perspective of synergistic antimicrobial mechanism. The synergetic effects of the combined application of antimicrobial peptides with traditional antimicrobial agents and their application in different fields are highlighted, aiming to further promote the innovation of antimicrobial application strategies such as antimicrobial peptides and inhibit the development of bacterial antimicrobial resistance.