儿童耐碳青霉烯类肠杆菌目细菌感染治疗药物研究进展

Research progress of drugs for treatment of carbapenem-resistant Ente-robacterales infection in children

摘要:

近年来，随着碳青霉烯类抗生素的广泛使用，儿童中耐碳青霉烯类肠杆菌目细菌（CRE）感染的病例越来越常见，且往往临床结局不良。由于儿童特殊的药代动力学/药效动力学（PK/PD）特征，多数抗CRE药物缺乏在这一群体中的临床应用经验，儿科医生在治疗CRE时面临巨大挑战。本文收集对儿童CRE感染的现有认识，就其流行病学、耐药机制以及最新的治疗策略进行综述，旨在为临床用药提供参考。

Abstract:

In recent years, with the widely application of carbapenems, carbapenem-resistant Enterobacterales (CRE) infection is increasingly prevalent in children, and are often associated with poor clinical outcomes. Due to the specific pharmacokinetic/pharmacodynamic (PK/PD) characteristics of children, most anti-CRE antimicrobial agents lack clinical application experience in children, and pediatricians face huge challenge in the treatment of CRE. In this paper, the existing knowledge of CRE infection in children is collected, epidemiology, antimicrobial resis-tance mechanisms and the latest treatment strategies are reviewed, so as to provide a reference for clinical medication.