长奈瑟菌致椎间隙感染1例报告

Intervertebral space infection caused by Neisseria elongate: one case report

摘要:

长奈瑟菌引起的椎间隙感染非常罕见, 本研究报告国内首次从椎间隙感染患者的组织标本中分离出长奈瑟菌病例。病原菌经VITEK MS全自动微生物质谱检测系统、VITEK 2 Compact全自动微生物分析系统和分子测序技术均鉴定为长奈瑟菌, 并依据临床实验室标准化协会(CLSI)M100 S-31对脑膜炎奈瑟菌的要求进行药敏试验及折点判读。临床结合细菌培养及药敏试验结果, 先后给予头孢噻肟/舒巴坦治疗6 d, 哌拉西林/他唑巴坦联合左氧氟沙星治疗7 d, 患者明显好转出院。现报告此病例的诊治过程及长奈瑟菌生物学特征, 以期为椎间隙长奈瑟菌感染的诊治提供指导依据。

Abstract:

Intervertebral space infection caused by Neisseria elongata (N. elongata) is very rare. This case is the first time that N. elongata has been isolated from tissue specimen of patient with intervertebral space infection. N. elongata was identified by VITEK MS automatic microbial mass spectrometry system, VITEK 2 Compact automatic microbial analysis system and molecular sequencing technology. Antimicrobial susceptibility test was performed and break point was interpreted according to requirements of Clinical and Laboratory Standard Institute (CLSI), M100 S-31. In combination with the results of bacterial culture and antimicrobial susceptibility testing, patient was treated with cefotaxime/sulbactam for 6 days and piperacillin/tazobactam combined with levofloxacin for 7 days respectively. Patient was obviously improved and discharged from hospital. The diagnosis and treatment process of this case and the biological characteristics of N. elongata are reported, so as to provide guidance basis for the diagnosis and treatment of intervertebral space infection caused by N. elongata.