血小板在抵御细菌感染和增强免疫中的地位

The role of platelet in resisting bacterial infection and enhancing immunity

摘要:

血小板具有止血和维持血管完整的基本功能，但近年研究证明其在细菌感染中担任重要的免疫防御角色。当机体出现细菌感染时，血小板第一个迁徙到感染前线，识别、捆绑、内吞病原菌或释放多种杀微生物蛋白直接杀灭细菌；同时增强中性粒细胞、单核细胞、补体系统的固有免疫功能，促T细胞、B细胞启动适应性免疫功能，协助共同清除机体细菌。

Abstract:

Platelet has the basic function of hemostasis and maintaining vascular integrity, recent studies have proved that it plays an important role in immune defense against bacterial infection. When bacterial infection occurs, platelet firstly migrate to the infection frontline to identify, bind, endocytose pathogens or release a variety of platelet microbicidal protein, which can directly kill bacteria, strengthen the innate immune function of neutrophil, monocyte and complement system, promote T lymphocyte and B lymphocyte to initiate adaptive immune responses against bacteria.