应用肺泡灌洗液荚膜多糖抗原早期诊断肺隐球菌病一例

Early diagnosis of pulmonary cryptococcosis with antigen of alveolar lavage fluid capsular polysaccharide: a case report

摘要:

报道1例应用胶体金免疫层析法（LFA）检测肺泡灌洗液（BALF）隐球菌荚膜多糖抗原早期诊断肺隐球菌病的病例，为肺隐球菌病的诊断提供参考。本例患者仅存在隐球菌肺部感染，入院时LFA对血清荚膜多糖抗原检测结果为阴性，但对BALF荚膜多糖抗原检测结果为阳性，考虑相比血清，BALF中可检测的荚膜多糖抗原较早出现阳性。故LFA检测BALF荚膜多糖抗原对肺隐球菌病早期诊断更有意义。

Abstract:

One case of early diagnosis of pulmonary cryptococcosis by detecting cryptococcal capsular polysaccharide antigen in bronchoalveolar lavage fluid (BALF) with lateral flow immunochromatographic assay(LFA) was reported, so as to provide reference for the diagnosis of pulmonary cryptococcosis. This patient only had Cryptococcus pulmonary infection, LFA was negative for detection of serum capsular polysaccharide antigen on admission, but positive for detection of BALF capsular polysaccharide antigen. Compared with serum, the detectable capsular polysaccharide antigen in BALF appeared positive earlier. Therefore, LFA detection of BALF capsular polysaccharide antigen is more significant for the early diagnosis of pulmonary cryptococcosis.