全髋关节置换术后罕见嗜沫凝聚杆菌感染——个案报告并文献复习

Rare prosthetic hip joint infection caused by Aggregatibacter aphrophilus after total hip arthroplasty: a case report and literature review

摘要:

人工关节感染是关节置换术后严重的并发症。嗜沫凝聚杆菌为苛养菌，某院收治的一例全髋关节置换术后髋关节穿刺液宏基因组二代测序及16S聚合酶链反应（PCR）检测均检出该菌，根据其检测结果对术中标本进行优化培养，最终培养出该菌并进行药敏检测。经人工髋关节二期翻修术及敏感抗菌药物治疗后，该患者成功治愈。此文就该例全髋关节置换术后罕见嗜沫凝聚杆菌感染病例进行报告及文献复习。

Abstract:

Prosthetic joint infection (PJI) is a serious complication after joint arthroplasty. Aggregatibacter aphrophilus (A. aphrophilus) is a fastidious bacteria, which was detected from hip joint puncture fluid after total hip arthroplasty of a patient in a hospital by both metagenomic next-generation sequencing(mNGS) and 16S polymerase chain reaction (16S PCR) detection, the optimal culture of intraoperative specimen was performed according to the detection results, A. aphrophilus was cultured finally and antimicrobial susceptibility testing was performed. After two-stage revision of hip arthroplasty and susceptible antimicrobial treatment, the patient was successfully cured. This paper reports and conducts literature review on a rare case of A. aphrophilus infection after total hip arthroplasty.