全国细菌耐药监测网2014-2019年耐碳青霉烯类肺炎克雷伯菌流行病学变迁

Epidemiological change in carbapenem-resistant Klebsiella pneumoniae:surveillance report from China Antimicrobial Resistance Surveillance in 2014-2019

摘要:

目的 了解中国耐碳青霉烯类肺炎克雷伯菌（CRKP）的耐药变迁。方法 分析2014-2019年全国细菌耐药监测报告中CRKP相关数据，比较不同地区、不同等级医院、不同标本来源、不同年龄组及不同科室CRKP的耐药变迁。结果 全国CRKP检出率从2014年的6.4%上升至2019年10.9%。2019年河南省及上海市CRKP检出率最高，分别为32.8%和28.7%，西藏检出率最低（为0.6%）；2019年全国儿童医院、三级医院及二级医院CRKP检出率分别为14.0%、11.6%及5.5%；2019年全国重症医学科患者CRKP检出率最高（23.0%），高于住院、急诊及门诊患者。结论 中国CRKP检出率呈现上升趋势，不同地区及不同科室间存在差异。

Abstract:

Objective To investigate the change in antimicrobial resistance of carbapenem-resistant Klebsiella pneumoniae (CRKP) in China. Methods Data of CRKP in report of China Antimicrobial Resistance Surveillance System(CARSS) from 2014 to 2019 were analyzed, change in antimicrobial resistance of CRKP in different areas, different levels of hospitals, different specimen sources, different age groups, and different departments were compared. Results Isolation rate of CRKP in China rose from 6.4% in 2014 to 10.9% in 2019. In 2019, the highest isolation rates of CRKP were in Henan Province and Shanghai City, which were 32.8% and 28.7% respectively, and the lowest rate was 0.6% in Xizang; in 2019, isolation rates of CRKP in children's hospitals, tertiary hospitals and secondary hospitals were 14.0%, 11.6% and 5.5% respectively; isolation rate of CRKP from patients in intensive care unit was the highest (23.0%), which was higher than those of other hospitalized patients, patients in outpatient department and emergency department. Conclusion Isolation rate of CRKP in China is on the rise, there are differences among different area and departments.