全身播散性偶发分枝杆菌病1例报告并文献复习

Systemic disseminated Mycobacterium fortuitum infection: one case report and literature review

摘要:

目的 探讨偶发分枝杆菌引起全身播散性感染的临床特点，以提高诊断率及对该病的认识。方法 报告全身播散性偶发分枝杆菌感染1例，并结合相关文献进行分析。结果 患者全身多系统累及（包括肺部、淋巴结、皮肤、关节），淋巴结组织培养偶发分枝杆菌阳性，给予克拉霉素+左氧氟沙星+利奈唑胺治疗，病情缓解。结论 偶发分枝杆菌引起全身播散性感染罕见，其机制可能与患者存在GATA2的缺乏和IFN-γ自身抗体有关，确诊主要依靠病理学及微生物学检查，但阳性率偏低，诊断困难。

Abstract:

Objective To explore the clinical characteristics of systemic disseminated infection caused by Mycobacterium fortuitum (M. fortuitum), and improve the diagnostic rate and understanding of the disease. Methods One case of systemic disseminated M. fortuitum infection was reported, and analyzed in combination with relevant literatures. Results Patient was with multiple systemic involvement (including lung, lymph node, skin, joint), lymph node tissue culture was positive for M. fortuitum, patient was given clarithromycin+levofloxacin+linezolid for treatment, disease was remitted. Conclusion Systemic disseminated M. fortuitum infection is rare, and patient with GATA2 deletion and IFN-γ autoantibody may be a potential mechanism, diagnosis is mainly based on patholo-gical morphology and microbiological detection, but positive rate is low, diagnosis is difficult.