鲍曼不动杆菌生物被膜形成与调控的研究进展

Research advances in Acinetobacter baumannii biofilm formation and regulation

摘要:

鲍曼不动杆菌是医院感染常见病原菌之一。鲍曼不动杆菌生物被膜形成可导致其在医院环境长期存在，耐药性和致病性增强，以及感染反复发生。生物被膜形成和调控是一个复杂的动态过程，受多种因素影响与多种机制调控。对生物被膜形成过程的影响因素和调控机制进行研究，可以帮助发现新的作用靶点，寻找新的抗菌药物治疗鲍曼不动杆菌感染。本文就鲍曼不动杆菌生物被膜形成过程、影响因素和调控机制的研究进展进行综述，以期为其感染防治提供方法及参考。

Abstract:

Acinetobacter baumannii (A. baumannii) is one of the common pathogens causing healthcare-associa-ted infection(HAI). The formation of A. baumannii biofilm can lead to its long-term presence in hospital environment, increase drug resistance and pathogenicity, and repeated occurrence of infection. Biofilm formation and regulation is a complex dynamic process, which is influenced by multiple factors and regulated by various mechanisms. The study on influencing factors and regulatory mechanisms of biofilm formation is conducive to finding new targets and searching new antimicrobial agents for the treatment of A. baumannii infection. In this paper, the progress of biofilm formation, influencing factors and regulatory mechanisms of A. baumannii are reviewed in order to provide methods and references for controlling its infection.