男男性接触者中肛肠尖锐湿疣患者合并淋球菌、沙眼衣原体感染现况

Neisseria gonorrhoeae and Chlamydia trachomatis infection in MSM with anorectal condyloma acuminatum

摘要:

目的了解男男性接触者（MSM）肛肠尖锐湿疣患者中合并肛肠淋球菌、沙眼衣原体感染现况，为肛肠尖锐湿疣患者的临床诊疗提供循证医学依据。方法分别采取MSM人群中已确诊肛肠尖锐湿疣患者（试验组）及非尖锐湿疣患者（对照组）的肛肠拭子，采用荧光定量PCR方法进行淋球菌及沙眼衣原体的核酸片段检测。同时采集调查对象的社会人口学及相关性行为学资料，进行比较分析。结果共纳入研究对象158例患者，其中试验组63 例，对照组95例。试验组63例患者中淋球菌感染率为17.46%，沙眼衣原体感染率为28.57%，同时合并淋球菌及沙眼衣原体感染率为12.70%；对照组中淋球菌感染率为6.32 %，沙眼衣原体感染率为9.47 %，同时合并淋球菌及沙眼衣原体感染率为2.16%。试验组患者肛肠中的淋球菌、沙眼衣原体感染率及两组疾病的合并感染率均高于对照组（均P＜0.05）。结论MSM中肛肠尖锐湿疣患者中具有较高的淋球菌及沙眼衣原体的感染率。提示医务人员临床工作中应重视肛肠尖锐湿疣患者肛肠部位的淋球菌、沙眼衣原体及其他性传播感染的筛查。

Abstract:

［Abstract］ObjectiveTo investigate anorectal infection with Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) among men who have sex with men (MSM) with anorectal condyloma acuminatum(CA), and provide evidence for the clinical diagnosis and treatment of anorectal CA.MethodsAnorectal swabs were obtained from MSM who were diagnosed with anorectal CA(trial group) and without CA(control group), nucleic acid fragments of NG and CT were detected by fluorescent quantitative polymerase chain reaction. Data about social demographic characteristics and sexual behaviors of investigated people were collected, compared and analyzed.ResultsA total of 158 patients were enrolled in this study, 63 were in trial group and 95 in control group. Among 63 patients in trial group, infection rate of NG and CT were 17.46% and 28.57% respectively, coinfection rate of NG and CT was 12.70%；in control group, infection rate of NG and CT were 6.32 % and 9.47 % respectively, coinfection rate of NG and CT was 2.16%；infection rate of NG and CT, as well as coinfection rate of NG and CT in trial group were all significantly higher than control group(all P<0.05).ConclusionInfection rate of NG and CT is high in MSM with anorectal CA，suggesting that more attention should be paid to the screening of NG, CT and other sexually transmitted infection among those who were clinically diagnosed with anorectal CA.