10例奴卡菌感染病例的临床特点及治疗

Clinical characteristics and therapy of 10 Nocardia infection cases

摘要:

目的分析奴卡菌感染病例的临床特点及治疗情况，为临床实践提供参考。方法回顾性调查2014年5月—2016年6月送检标本中培养出奴卡菌的患者，对其机体状况、临床特点、治疗方案以及预后进行分析。结果共调查10例奴卡菌感染病例。男性7例，女性3例；平均年龄（49.90±13.75）岁。多发生于免疫状况受损或者有基础疾病的人群，主要感染部位为肺部，复方磺胺甲口恶唑为首选药物，或视病情联合阿米卡星、亚胺培南/西司他丁等。8例患者经过治疗后病情好转。结论依据微生物检验、影像学和病理学检查结果进行诊断，并结合奴卡菌感染的高危因素进行综合判断，可使患者得到及时合理治疗，预后较好。 

Abstract:

ObjectiveTo analyze the clinical characteristics and therapy of Nocardia infection, and provide reference for clinical practice．MethodsPatients with positive specimen culture of Nocardia from May 2014 to June 2016 were surveyed retrospectively, the body status, clinical features, therapeutic regimen, and prognosis were analyzed. ResultsA total of 10 cases of Nocardia infection were surveyed, there were 7 males and 3 females; average age was (49.90+13.75) years old. Nocardia infection occurred mostly in population with impaired immune status or underlying diseases, the main infection site was lung, compound sulfamethoxazole was the first choice drug for treatment of infection, amikacin, imipenem/cilastatin and so on were alternative choice according to disease condition, 8 patients all improved after therapy.ConclusionThe diagnosis made on the basis of microbiological examination, imaging, and pathological examination, combined with comprehensive judgment according to risk factors of Nocardia infection, patient can be treated timely and rationally, and the prognosis is better.