克林霉素联合复方磺胺甲口恶唑片治疗艾滋病合并肺孢子菌肺炎的疗效分析

Therapeutic effect of clindamycin combined with compound sulfamethoxazole tablets on pneumocystis pneumonia associated with acquired immunodeficiency syndrome

摘要:

目的了解克林霉素联合复方磺胺甲口恶唑片治疗艾滋病合并肺孢子菌肺炎（PCP）的治疗效果。方法收治2014年1月—2015年3月某院艾滋病合并PCP患者97例，根据治疗方案不同分为对照组（给予复方磺胺甲口恶唑片进行治疗，49例）和实验组（在对照组治疗基础上加入克林霉素进行治疗，48例），记录治疗前后两组患者血氧指标-动脉血氧分压（PaO2）、动脉血氧饱和度（SaO2）水平、血清清蛋白（ALB）和血乳酸脱氢酶（LDH）等水平变化。结果两组患者治疗前血氧指标PaO2、SaO2、ALB和LDH水平比较，差异无统计学意义（均P>0.05）。治疗后对照组和实验组的PaO2分别为（73.01±4.62）mmHg、（84.92±5.34）mmHg，SaO2分别为（75.81±4.28）%、（90.86±5.94）%，ALB分别为（32.62±4.41）g/L、（43.95±5.03）g/L，LDH分别为（416.53±30.77）U/L、（331.58±20.86）U/L，治疗后实验组PaO2和SaO2水平均高于对照组，实验组和对照组ALB和LDH水平比较，差异均有统计学意义（均P<0.05）。实验组总有效率为89.58%（43例），高于对照组的69.39%（34例），差异有统计学意义（χ2 =6.04，P=0.014）。结论克林霉素联合复方磺胺甲口恶唑片对艾滋病合并PCP患者具有良好的治疗效果，值得临床推广和应用。

Abstract:

ObjectiveTo understand the therapeutic effect of clindamycin combined with compound sulfamethoxazole tablets on pneumocystis pneumonia(PCP) associated with acquired immunodeficiency syndrome (AIDS). Methods97 AIDS patients with PCP in a hospital from January 2014 to March 2015 were randomly divided into control group (n=49, received compound sulfamethoxazole ) and trial group(n=48, received clindamycin on the basis of compound sulfamethoxazole ) , levels of partial pressure of oxygen in arterial blood (PaO2), arterial blood oxygen saturation（SaO2）, serum albumin(ALB), and lactic dehydrogenase (LDH）in two groups of patients before and after treatment were recorded. ResultsLevels of PaO2, SaO2, ALB, and LDH between two groups of patients before treatment was not significantly different(all P>0.05). After treatment, PaO2 in control group and trial group were（73.01±4.62）mmHg and（84.92±5.34）mmHg respectively，SaO2  were （75.81±4.28）% and（90.86±5.94）% respectively，ALB were (32.62±4.41)g/L and（43.95±5.03）g/L respectively，LDH were（416.53±30.77）U/L and（331.58±20.86）U/L respectively，levels of PaO2 and  SaO2 in trial  group were both higher than control group , difference in ALB and LDH between two groups of patients after treatment were both statistically significant( both P<0.05). The total effective rate of trial group was 89.58% (n=43), which was higher than 69.39%(n=34) in control group （χ2 =6.04，P=0.014）. ConclusionClindamycin combined with compound sulfamethoxazole tablets has good therapeutic effect on AIDS and PCP, which is worthy of clinical popularization and application.