某院重症医学科2010—2013年鲍曼不动杆菌耐药性监测

Monitoring of antimicrobial resistance of Acinetobacter baumannii in the intensive care unit of a hospital from 2010 to 2013

摘要:

目的分析重症医学科2010—2013年鲍曼不动杆菌(AB)的检出率及耐药特征，为临床抗感染治疗提供依据。方法对某院重症医学科2010—2013年AB检出情况、耐药性进行回顾性分析。结果2010—2013年共分离病原菌1 413株，其中AB共556株，占39.35%，每年AB检出率分别是39.45%、41.35%、29.44%、40.53%。AB主要来源于下呼吸道(占75.72%)。药敏试验结果显示耐药率较低的抗菌药物是头孢哌酮/舒巴坦（5.85%）和阿米卡星（17.45%）；2010—2013年多重耐药、泛耐药AB检出率分别从9.63%、3.70%，上升至42.50%、31.88%，差异均有统计学意义（均P＜0.001）。结论AB是重症医学科最常见致病菌，对抗菌药物耐药严重，多重耐药、泛耐药AB检出率逐年增加；加强对AB的耐药性监测，有利于治疗和预防AB感染。

Abstract:

ObjectiveTo analyze the isolation rates and antimicrobial resistance of Acinetobacter baumannii(AB) from intensive care unit(ICU) between 2010 and 2013, and provide evidence for clinical antiinfective therapy.MethodsThe isolation and antimicrobial resistance of AB from ICU between 2010 and 2013 were analyzed retrospectively.ResultsA total of 1 413 pathogenic strains were isolated, 556(39.35%) of which were AB, isolation rates in each year were 39.45%,41.35%,29.44%,and 40.53% respectively. AB were mainly isolated from lower respiratory tract (75.72%). Antimicrobial susceptibility testing results showed that AB had low resistance rates to cefoperazone/sulbactam（5.85%）and amikacin （17.45%）；detection rates of multidrugresistant and extensively drugresistant AB increased from 9.63% and 3.70% to 42.50% and 31.88%，respectively（both P＜0.001）.ConclusionAB is the common pathogen in ICU, antimicrobial resistance is serious, isolation of multidrugresistant and extensively drugresistant AB increased year by year； intensifying the monitoring of drug resistance is helpful for the treatment and prevention of AB infection.