黏液型肺炎克雷伯菌耐药性

Antimicrobial resistance of mucoid Klebsiella pneumoniae

摘要:

目的了解黏液型肺炎克雷伯菌的科室分布和耐药性，为临床治疗选药和医院感染控制提供依据。方法收集某院2013年1—12月临床分离的180株肺炎克雷伯菌株，筛选黏液型菌株，采用VITEK 2 Compact 鉴定系统进行菌株鉴定及药敏测定。结果共获得28株黏液型肺炎克雷伯菌，主要标本来源为呼吸道，主要科室分布为神经外科。肺炎克雷伯菌对亚胺培南、哌拉西林/他唑巴坦、头孢他啶、环丙沙星、阿米卡星体外敏感率,黏液型分别为96.43%、96.43%、89.29%、92.86%、96.43%，非黏液型分别为78.29%、78.29%、69.08%、72.37%和78.29%。结论肺炎克雷伯菌的体外敏感率黏液型高于非黏液型，但临床治疗时应考虑其生物膜的存在, 选择合适的药物进行治疗。

关键词:

肺炎克雷伯菌; 黏液型; 抗药性，微生物; 抗菌药物; 生物膜

Abstract:

ObjectiveTo  investigate department distribution and antimicrobial resistance of mucoid Klebsiella pneumoniae(K. pneumoniae),so as to provide reference  for rational antimicrobial use and control of healthcareassociated infction.Methods80  K.pneumoniae isolates from clinic in JanuaryDecember 2013 were collected, mucoid  strains were selected, bacterial identification and antimicrobial susceptibility testing were performed by VITEK2 Compact identification system.ResultsA total of 28 mucoid K.pneumoniae isolates were obtained,  strains were mainly from respiratory specimens, the main departments were neurosurgical department. Susceptibility rates of mucoid K. pneumoniae to imipenem, piperacillin / tazobactam, ceftazidime,ciprofloxacin, and amikacin was 96.43%,96.43%,89.29%,92.86%, and 96.43%, respectively,nonmucoid K. pneumoniae  to above antimicrobial agents was 78.29%,78.29%,69.08%,72.37%, and 78.29% respectively.ConclusionAntimicrobial susceptibility rates of mucoid  K. pneumoniae are significantly higher than nonmucoid strains in vitro, biofilm should be considered in clinical therapy, antimicrobial agents should be chosen rationally.

Key words:

Klebsiella pneumoniae; mucoid; drug resistance, microbial; antimicrobial agent;biofilm