同时入院9例大面积烧伤患者感染病原菌及其耐药性变迁

Change trend and antimicrobial resistance of pathogens causing infection in extensive burn patients

摘要:

目的探讨大面积烧伤患者感染病原菌的变化趋势及耐药情况，为临床防治提供参考。方法采集2014年8月2日同批入院的9例大面积烧伤患者各部位标本，送微生物室进行病原菌培养及药敏试验，跟踪观察感染菌株变化及药敏情况。结果标本类型以创面分泌物为主，占93.81%。感染病原菌主要为鲍曼不动杆菌（占44.85%），其次为金黄色葡萄球（占32.47%）、铜绿假单胞菌（占12.37%）、肺炎克雷伯菌（占5.15%）等。随住院时间延长，感染细菌由1种向多种细菌变迁，细菌的耐药性呈敏感到耐药或多耐药，再到泛耐药的发展趋势。结论烧伤患者感染不可避免，应及时了解感染病原菌及其变迁与耐药情况，对感染控制可起到积极作用。

关键词:

大面积烧伤; 病原菌; 细菌; 变迁; 抗药性，微生物; 合理用药; 感染控制

Abstract:

ObjectiveTo explore the change trend and antimicrobial resistance of pathogens causing infection in extensive burn patients, and provide reference for clinical prevention and treatment.MethodsSpecimens from 9 extensive burn patients who were admitted to a hospital at the same time were performed pathogenic culture and antimicrobial susceptibility testing, change trend and antimicrobial susceptibility of pathogens were observed.ResultsThe main specimen was wound secretion, accounting for 93.81%. The major pathogens causing infection were Acinetobacter baumannii (44.85%), Staphylococcus aureus (32.47%), Pseudomonas aeruginosa (12.37%), and Klebsiella pneumoniae (5.15%). With the prolongation of hospital stay, pathogens changed from one kind to multiple strains, and from susceptibility to resistance,multidrug resistance,and extensive drug resistance. ConclusionIt is difficult to avoid infection in burn patients, timely realizing the changes of pathogens causing infection and antimicrobial resistance play an important role in the control of infection.

Key words:

extensive burn; pathogens; bacteria; change; drug resistance, microbial; rational use of drug; infection control