血降钙素原、D二聚体检测在脓毒血症预后判断中的应用

Application of plasma procalcitonin and Ddimer measurements in estimating the prognosis of patients with sepsis

摘要:

目的探讨血降钙素原、D二聚体检测对脓毒血症患者预后判断的临床价值。方法将68例脓毒血症患者按预后分为生存组和死亡组，比较两组间血降钙素原、D二聚体水平并根据患者病情计算急性生理与慢性健康状况评分(APACHEⅡ)，判断各指标对脓毒血症患者预后的预测价值。结果68例脓毒血症患者，生存组28例，死亡组40例，病死率58.82%。两组降钙素原、D二聚体水平及APACHEⅡ评分经统计学分析，差异均有统计学意义（均P＜0.05），死亡组均显著高于生存组。降钙素原、D二聚体水平与APACHEⅡ评分存在明显正相关性（P＜0.05）。结论降钙素原、D二聚体水平与APACHEⅡ评分可用于评估脓毒血症患者病情，并作为预后预测的依据。

关键词:

降钙素原; D二聚体; 脓毒血症; APACHEⅡ评分; 感染; 预后

Abstract:

ObjectiveTo evaluate the clinical value of plasma procalcitonin and Ddimer measurements in estimating the prognosis of patients with sepsis. MethodsAccording to prognosis,68 patients with sepsis were divided into survival group and death group，levels of procalcitonin and Ddimer, and acute physiology and chronic health evaluation II (APACHE II) of two groups of patients were compared, predictive value of above markers in estimating the prognosis of patients with sepsis were evaluated.ResultsOf 68 patients with sepsis, 28 survived and 40 died,mortality was 58.82%. There were significant differences in levels of procalcitonin and Ddimer,as well as APACHE II between two groups(both P<0.05), death group were all higher than survival group.Procalcitonin and Ddimer level were positively correlated with APACHE II score（P＜0.05）.ConclusionProcalcitonin, Ddimer level and APACHE II score can be used to evaluate condition of patients with sepsis as well as the prognosis of disease.

Key words:

procalcitonin; Ddimer; sepsis; APACHE II score; infection; prognosis