不同病区分离的鲍曼不动杆菌耐药性差异

Difference in antimicrobial resistance of Acinetobacter baumannii isolated from patients at different wards

摘要:

目的了解鲍曼不动杆菌在不同病区的医院感染现状及耐药性差异，为有效预防及治疗医院鲍曼不动杆菌感染提供依据。方法回顾性分析某院2012年1月—2013年7月住院患者送检标本中分离的446株鲍曼不动杆菌资料。结果446株鲍曼不动杆菌主要分离自重症监护室（ICU；236株，52.92%),其次是呼吸内科(55株，12.33%)和神经外科（48株，10.76%）；均主要来源于痰标本（共占94.62％）。13种常用抗菌药物的药敏结果显示，ICU分离的鲍曼不动杆菌耐药性最强，其敏感率均＜20%；神经外科分离株耐药性次之，敏感率均＜30%；而呼吸内科分离株敏感率均＞50%，耐药率最低。结论不同病区分离的鲍曼不动杆菌耐药性差异较大，ICU分离株耐药性最严重。

Abstract:

ObjectiveTo investigate the difference in healthcareassociated infection (HAI) status and antimicrobial resistance of Acinetobacter baumannii（A. baumannii） isolated from different wards, so as to provide evidence for effective prevention and therapy for HAI caused by A. baumannii.MethodsClinical data of 446 A. baumannii isolates from hospitalized patients between January 2012 and July 2013 were analyzed retrospectively. ResultsThe majority of 446 A. baumannii isolates were from patients admitted to intensive care unit (ICU, n=236,52.92%), followed by departments of respiratory diseases(n=55,12.33%) and neurosurgery (n=48,10.76%),and the strains were mainly isolated from sputum specimens (94.62%).Antimicrobial susceptibility testing with 13 kinds of commonly used antimicrobial agents showed that antimicrobial resistance of A. baumannii from ICU were highest, susceptibility rates were all <20%, the next were from department of neurosurgery, susceptibility rates were all<30%, while susceptibility rates of A. baumannii from department of respiratory diseases were all >50%.ConclusionThe difference in antimicrobial resistance of A. baumannii from different wards varied significantly, antimicrobial resistance of A. baumannii from ICU is most serious.