多重耐药鲍曼不动杆菌体外抗菌活性分析

In vitro activity of antimicrobial agents against multidrugresistant Acinetobacter baumannii

摘要:

目的了解抗菌药物对多重耐药鲍曼不动杆菌的体外抗菌活性。方法 对某院2013年1—5月临床各科室送检标本分离的224株多重耐药鲍曼不动杆菌进行鉴定及药敏试验。结果224株多重耐药鲍曼不动杆菌主要分布在呼吸内科（21.43%），其次是脑外科（16.07%）、脑外重症监护室（ICU，12.50%）和神经内科（12.50%）等。标本来源以痰液（57.14%）为主，其次是气管插管（16.52%）和引流液（9.82%）等。多重耐药鲍曼不动杆菌对替加环素敏感，对米诺环素耐药率为7.14%，对其余8种抗菌药物的耐药率均≥75%，其中头孢替坦耐药率高达98.21%。结论替加环素对该院多重耐药鲍曼不动杆菌具有良好的抗菌效果。

Abstract:

ObjectiveTo evaluate in vitro activity of antimicrobial agents against multidrugresistant Acinetobacter baumannii (MDR A.baumannii).Methods224 MDR A.baumannii strains isolated from specimens of clinical departments in a hospital between January and May 2013 were identified and performed antimicrobial susceptibility testing.Results224 MDR A.baumannii strains were mainly isolated from respiratory disease department(21.43%), neurosurgical department(16.07%), neurosurgical intensive care unit(12.50%), and neurology department(12.50%). The major specimens of A.baumannii was sputum(57.14%),the next were tracheal intubation(16.52%) and drainage fluid(9.82%). MDR A.baumannii strains were sensitive to tigecycline, the resistant rate to minocycline was 7.14%,to the other eight antimicrobial agents were all ≥75%, resistant rate to cefotetan was up to 98.21%.ConclusionTigecycline is highly effective against MDR A.baumannii in this hospital.