儿童产超广谱β内酰胺酶细菌感染耐药性研究 FREE

Antimicrobial resistance of extendedspectrum betalactamaseproducing bacterial infection in children FREE

摘要:

目的比较儿童送检标本分离的产超广谱β内酰胺酶(Extendedspectrum betalactamase, ESBLs)细菌的耐药性，为临床抗ESBLs菌株感染治疗提供参考依据。方法抽取山西省儿童医院2007年1月—2009年4月各类送检标本分离的ESBLs阳性和阴性菌株各100株进行耐药性比较。结果200株菌株对亚胺培南全部敏感；而对其他11种抗菌药物的耐药性，ESBLs阳性菌株均高于ESBLs阴性菌株（P≤0.001）。其中ESBLs阳性菌株除对头孢哌酮/舒巴坦的耐药率较低（13.00%）外，对其余头孢类抗生素的耐药率均＞98%；对庆大霉素和环丙沙星的耐药率分别高达69.07%和59.18%。结论儿童分离的ESBLs阳性菌对碳青霉烯类或加酶抑制剂复合抗菌药物（如头孢哌酮/舒巴坦）较敏感。

关键词:

超广谱β内酰胺酶;抗药性，微生物;儿童;大肠埃希菌;肺炎克雷伯菌

Abstract:

ObjectiveTo study the antimicrobial resistance of extendedspectrum betalactamase(ESBLs)producing bacteria isolated from children, so as to provide reference for treating infections with ESBLsproducing bacteria. MethodsOne hundren ESBLsproducing strains and 100 nonESBLsproducing strains were randomly selected from Children’s Hospital of Shanxi Province between January 2007 and April 2009, and their antimicrobial resistance were campared. ResultsAll 200 strains were sensitive to imipenem; the resistance of ESBLspositive strains to the other 11 kinds of antimicrobial agents were higher than that of ESBLsnegative strains (P≤0.001). Except resistance to cefoperazone/sulbactam was low (13.00%), the resistance of ESBLspositive strains to the other cephalosporins were all>98%; The resistant rate to gentamycin and ciprofloxacin was 69.07% and 59.18% respectively. ConclusionESBLsproducing strains isolated from children are sensitive to carbapenems or antimicrobial compound inhibitors (such as cefoperazone /sulbactam).

Key words:

extendedspectrum betalactamase;drug resistance, microbial; child; Escherichia coli;Klebsiella pneumonia