防感汤对手足口病的预防效果研究 FREE

Effect of anticommon cold broth on preventing handfootmouth disease FREE

摘要:

目的探讨防感汤预防婴幼儿手足口病感染,减轻感染症状的作用。方法采用随机对照现场试验方法，比较试验组（在标准预防控制措施基础上给予预防药物——防感汤）和对照组（采取标准预防控制措施）的继发感染率及临床症状发生率，并对研究结果进行多重Logistic回归分析。结果试验组继发感染率为21.90%（23/105），对照组为51.09%（47/92），试验组继发感染率显著低于对照组（P＜0.001，OR=0.27，95%CI为0.15～0.50）。利用COX模型拟合条件Logistic回归，结果试验组感染优势为对照组的0.31倍（P=0.00，95% CI为0.20～0.48）。试验组隐性感染17例（构成比73.91%，17/23）,对照组21例（构成比44.68%,21/47），经ChiSquare 检验，试验组隐性感染率显著高于对照组（P=0.02，OR=3.51，95%CI为1.18～10.48）。利用Logistic回归分析病毒类型、年龄、性别等因素对隐性感染的影响，结果试验组隐性感染优势为对照组的3.17倍（P=0.01，95% CI为 1.30～9.75）。结论防感汤能在一定程度上预防手足口病的感染，减轻感染症状。

Abstract:

ObjectiveTo study the  effect of anticommon cold broth on the prevention and remission of  handfootmouth disease(HFMD).MethodsUsing on the spot trial, secondary infection rate and  incidence rate of clinical symptoms were compared between trial group (anticommon cold broth on the basis of standard prevention and control)  and control group (standard prevention and control ) , and  results were analysed with Logistics regression analysis.ResultsThe secondary infection rate in  trial group and control group was 21.90%（23/105）and 51.09%（47/92）respetively, the former was significantly lower than the latter（p＜0.001，OR=0.27，95%CI:0.15～0.50）. Conditional Logistic regression fitted by COX model revealed that the adjusted odds ratio was 0.31（P=0.00，95% CI:0.20～0.48）. There were 17 cases(constitutional ratio:73.91%, 17/23) in trial group and 21 cases(constitutional ratio:44.68%, 21/47) in control group had latent infection , the constitutional ratio of latent infection in trial group was higher than the control group（P=0.02,OR=3.51，95%CI:1.18～10.48）.Logistic regression was used to adjust the contributions of the types of virus, age and gender, the results reveal that the odds ratio of latent infection of the trial group by the control group was 3.17(P=0.01，95% CI: 1.30～9.75）.ConclusionAnticommon cold broth can prevent the secondary infection of HFMD, and relieve its symptoms .