铜绿假单胞菌对β内酰胺类抗生素的耐药性变迁 FREE

Change in drugresistance of Pseudomonas aeruginosa to βlactam antibiotics FREE

摘要:

目的调查某院铜绿假单胞菌对β内酰胺类抗生素的耐药性及其变迁，为临床治疗铜绿假单胞菌感染提供参考依据。方法分析1999—2007年分离的2 127株铜绿假单胞菌对18种β内酰胺类抗生素的药敏结果。结果9年来铜绿假单胞菌对18种β内酰胺类抗生素的耐药率逐年上升，各年度差异有显著性（P＜0.05或P＜0.01）。只有美罗培南、亚胺培南和头孢他啶的总耐药率＜30%。结论铜绿假单胞菌对多种β内酰胺类抗生素耐药，且耐药率逐年增加，应适当控制第三代头孢菌素和碳青霉烯类药物的使用，以有效控制及延缓耐药株的产生。

Abstract:

To investigate the change in  drugresistance of Pseudomonas aeruginosa (P. aeruginosa) to βlactam antibiotics in a hospital, so as to provide reference for treatment of P. aeruginosa infection.MethodsDrug sensitivity tests of 2 127 strains of P. aeruginosa isolated fom clinic between 1999—2007 to 18 kinds of antibiotics were analysed.ResultsResistance of P. aeruginosa to 18 kinds of βlactam antibiotics  increased year by year during  the past 9 years, there was significant difference between each year (P<0.05 or P<0.01). The total resistant rates to meropenem, imipenem and ceftazidime were below 30%. ConclusionP. aeruginosa was resistant to many kinds of βlactam antibiotics, and resistant rate increased year by year, in order to control and slow down the emergence of the resistant strains , the use of third generation cephalosporins and carbapenems should be properly controlled .