平均血小板内容物浓度测定与血小板计数在脓毒症诊疗中的应用 FREE

Detection of mean platelet components and platelet count in the diagnosis and treatment of sepsis FREE

摘要:

目的探讨脓毒症患儿平均血小板内容物浓度（Mean platelet component,MPC）变化及其意义。方法采集93例脓毒症患儿入院24 h内静脉血,用ADVIA2120全自动血细胞分析仪检测血小板计数(PC)、MPC，并与健康对照组(体检合格儿童)进行比较；同时将脓毒症患儿分为一般脓毒症组和重症脓毒症组进行比较。结果93例脓毒症患儿PC、MPC水平分别为(101.00±49.00)×109/L、(225.00±20.00)g/L,明显低于健康对照组的(212.00±72.00)×109/L、(267.00±22.00)g/L(均P＜0.05)；40例重症脓毒症患儿PC、MPC值分别为(86.00±35.00)×109/L、(213.00±13.00)g/L,明显低于53例一般脓毒症患儿的(141.00±40.00)×109/L、(235.00±18.00)g/L(均P＜0.05)。当PC临界值为100.00×109/L，MPC临界值为267.00 g/L时，53例一般脓毒症患儿中有20例PC降低，灵敏度为37.74%；51例MPC降低，灵敏度为96.23%。结论常规检测脓毒症患儿的PC、MPC变化趋势,尤其早期检测MPC,可能成为评价脓毒症病情的一种快速、可信的手段。

Abstract:

To explore the clinical significance of mean platelet components (MPC)  in children with sepsis.MethodsIntravenous blood of 93 children with sepsis within 24 hours of admission were collected, platelet count (PC) and MPC were analysed  by  ADVIA 2120 hematocyte system, and results were compared with healthy  control; severe and mild group of children with sepsis was compared.ResultsThe levels of PC and MPC of all children with sepsis were (101.00±49.00)×109/ L and (225.00±20.00) g/L respectively, which  were significantly lower than (212.00±72.00)×109/ L and (267.00±22.00) g/L in healthy group respectively (both P<0.05). The levels of PC and MPC of 40 children with severe sepsis  were (86.00±35.00)×109/ L and (213.00±13.00) g/L respectively, which  were significantly lower than (141.00±40.00)×109/L and  (235.00±18.00) g/L in mild sepsis group respectively (both P<0.05). When the critical value of PC and MPC were 100.00×109/L  and 267.00 g/L, among 53 children with mild sepsis, PC values of 20 children and MPC values of 51 children were all decreased, the sensitivity was 37.74% and 96.23% respectively. ConclusionThe routine detection of PC and MPC,  especially MPC at  the early stage, can be considered as a quick and reliable guide in the assessment of the extent of  sepsis.